The uncapped fixture will see the two sides compete for the Quilter Cup, with this new name reflecting England partner Old Mutual Wealth’s plans to separate from its parent company and list on the London and Johannesburg stock exchanges in 2018 under its new name Quilter.
England’s men’s and women’s autumn internationals will also adopt the new name and be known as the Quilter Internationals from 2018.
In last season’s match, England beat the Barbarians 28-14 which saw head coach Eddie Jones give a number of new faces their first opportunity in an England shirt including Tom Curry, Nick Isiekwe, Alex Lozowski and Sam Underhill. All four went on to win full caps for their country during England’s summer Test series in Argentina a few weeks later.
"The Quilter Cup is an important match for us as we prepare for our three Test series against South Africa in June," said Jones.
"The series will be a big challenge for this team and we know the Barbarians will provide us a fantastic opportunity to play against some high-quality opposition before the tour. The Barbarians brand of rugby is well known for being exciting and open and we will look forward to playing them in May in front of a big crowd at Twickenham."